(S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Base Information

Chemical Name:(S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol
CAS No.:1280193-92-1
Molecular Formula:C₂₃H₂₇Cl₂N₃O₂
Molecular Weight:448.392
Hs Code.:

Synonyms:(S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Suppliers and Price of (S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

There total 6 articles about (S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 956199-27-2
1-(1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-N-methylmethanamine

: 129098-57-3
(S)-1,2-epoxy-3-(4-chlorophenoxy) propane

: 1280193-92-1
(S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Guidance literature:: With potassium carbonate; In acetonitrile; for 0.833333h; under 6750.68 Torr; optical yield given as %ee; Microwave irradiation; Inert atmosphere;
DOI:10.1021/jm2003365

Reference yield:

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 1280193-92-1
(S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: ethanol / 2 h / 60 °C / Inert atmosphere

2.2: 21 h / 75 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 0.83 h / 6750.68 Torr / Microwave irradiation; Inert atmosphere

With potassium carbonate; potassium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile; 2.1: Mannich-type reaction / 2.2: Mannich-type reaction;
DOI:10.1021/jm2003365

Reference yield:

: 2212-05-7
4-chlorophenyl 2,3-epoxypropyl ether

: 1280193-92-1
(S)-1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-chlorophenoxy)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: (R,R)-(-)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II); water; acetic acid / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 0.83 h / 6750.68 Torr / Microwave irradiation; Inert atmosphere

With (R,R)-(-)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II); water; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm2003365