RACEMIC-4,12-DIHYDROXY[2,2]PARACYCLOPHANE

Base Information

• Chemical Name: RACEMIC-4,12-DIHYDROXY[2,2]PARACYCLOPHANE
• CAS No.: 612492-27-0
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.302
• Mol file: 612492-27-0.mol

Synonyms:RACEMIC-4,12-DIHYDROXY[2,2]PARACYCLOPHANE;racemic-4,12-Dihydroxy[2.2]paracyclophane,min.97%

Chemical Property of RACEMIC-4,12-DIHYDROXY[2,2]PARACYCLOPHANE

Chemical Property:

• Melting Point: >300 °C
• Boiling Point: 414.8±45.0 °C(Predicted)
• PKA: 9.90±0.20(Predicted)
• PSA: 40.46000
• Density: 1.211±0.06 g/cm3(Predicted)
• LogP: 2.98160

Purity/Quality:

98% ^*data from raw suppliers

racemic-4,12-Dihydroxy[2.2]paracyclophane, min. 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RACEMIC-4,12-DIHYDROXY[2,2]PARACYCLOPHANE

There total 45 articles about RACEMIC-4,12-DIHYDROXY[2,2]PARACYCLOPHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C36H40O8 → (R)-(+)-4,12-dihydroxy[2.2]paracyclophane (612492-27-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.tetasy.2004.02.011

Reference yield: 97.0%

C36H40O8 → (S)-(-)-4,12-dihydroxy[2.2]paracyclophane (612492-27-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.tetasy.2004.02.011

Reference yield: 83.0%

4,16-dibromo[2.2]paracyclophane (196316-30-0,196316-31-1,23927-40-4,96392-77-7) → 1,4(1,4)-dibenzenacyclohexaphane-12,43-diol (24262-20-2,612492-27-0)

Guidance literature:

4,16-dibromo[2.2]paracyclophane; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 1h;

With Trimethyl borate; In diethyl ether; hexane; at 0 - 20 ℃; for 3h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In diethyl ether; hexane; water; at 20 ℃; for 3h;

DOI:10.1055/s-0036-1588898

upstream raw materials:

[2.2]Paracyclophan

4,16-dibromo[2.2]paracyclophane

4,12-dihydroxy-5,13-dipentanoyl[2.2]paracyclophane

4-formyl[2.2]paracyclophane

Downstream raw materials:

4-hydroxy-[2,2]-paracyclophane

(R_p)-(+)-4-hydroxy-[2.2]paracyclophane

Refernces

• 1、 Pilevar, Afsaneh,Hosseini, Abolfazl,?ekutor, Marina,Hausmann, Heike,Becker, Jonathan,Turke, Kevin,Schreiner, Peter R.. "Tuning the Reactivity of Peroxo Anhydrides for Aromatic C-H Bond Oxidation". . p. 10070 - 10079. Retrieved 2018/09/06.
• 2、 Moorthy, Jarugu Narasimha,Mandal, Susovan,Kumar, Amrit. "Photochromism of novel chromenes constrained to be part of [2.2]paracyclophane: Remarkable 'phane' effects on the colored o-quinonoid intermediates". . p. 82 - 88. Retrieved 2013/02/25.