1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene

Base Information

• Chemical Name: 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene
• CAS No.: 445039-49-6
• Molecular Formula: C₂₂H₁₉FO₅S
• Molecular Weight: 414.454

Synonyms:1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene

Chemical Property of 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene

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Technology Process of 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene

There total 4 articles about 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-fluoro-5-methylphenyl)(6-(4-methylthiophenyl)(2H-benzo[d]1,3-dioxolan-5-yl))methan-1-ol (445039-91-8) → 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene (445039-49-6)

Guidance literature:

With Oxone; In methanol; at 20 ℃; for 2h;

DOI:10.1021/jm030268b

Reference yield:

piperonal (120-57-0,30024-74-9) → 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene (445039-49-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / bromine; acetic acid; iodine / CS₂ / 20 °C

2: 88 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / ethanol / Heating

3: tetrahydrofuran

4: aq. oxone / methanol / 2 h / 20 °C

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; iodine; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; carbon disulfide; ethanol; 2: Suzuki coupling;

DOI:10.1021/jm030268b

Reference yield:

6-bromo-3,4-methylenedioxybenzaldehyde (15930-53-7) → 1-(6-((2-fluoro-5-methylphenyl)hydroxymethyl)(2H-benzo[3,4-d]1,3-dioxolan-5-yl))-4-(methylsulfonyl)benzene (445039-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / ethanol / Heating

2: tetrahydrofuran

3: aq. oxone / methanol / 2 h / 20 °C

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; methanol; ethanol; 1: Suzuki coupling;

DOI:10.1021/jm030268b

upstream raw materials:

(2-fluoro-5-methylphenyl)(6-(4-methylthiophenyl)(2H-benzo[d]1,3-dioxolan-5-yl))methan-1-ol

piperonal

6-bromo-3,4-methylenedioxybenzaldehyde

6-(4-methylthiophenyl)-2H-benzo[d]1,3-dioxolane-5-carbaldehyde

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