tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate
CAS No.:191851-21-5
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

Synonyms:tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

There total 12 articles about tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191851-20-4
C₄₀H₄₉NO₅Si

: 191851-21-5
tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1567687-80-2
C₁₉H₂₃NO₃

: 191851-21-5
tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; In ethyl acetate; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c3ra47555g

Reference yield:

: 1579996-41-0
(2R,3R,4R)-1-benzyl-3,4-bis(benzyloxy)-2-(trityloxymethyl)-pyrrolidine

: 191851-21-5
tert-butyl (2R,3R,4R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 1 h / 20 °C / 760.05 Torr / Inert atmosphere

3: sodium carbonate / ethyl acetate / 2 h / 20 °C / Inert atmosphere

With 10 wt% Pd(OH)2 on carbon; hydrogen; sodium carbonate; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1039/c3ra47555g