4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile

Base Information

• Chemical Name: 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile
• CAS No.: 1326231-32-6
• Molecular Formula: C₂₀H₁₃ClN₆O₂
• Molecular Weight: 404.815

Synonyms:4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile

Chemical Property of 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile

There total 2 articles about 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) + 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzonitrile (116133-09-6) → 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile (1326231-32-6)

Guidance literature:

In acetone; at 40 - 45 ℃;

DOI:10.1002/jhet.1769

Reference yield:

4-Aminobenzonitrile (873-74-5) → 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile (1326231-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran

2: sodium hydride / tetrahydrofuran; mineral oil / 8 h / 45 °C

With sodium hydride; triethylamine; In tetrahydrofuran; mineral oil;

DOI:10.1016/j.jfluchem.2011.06.021

Reference yield: 96.0%

4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile (1326231-32-6) + cyclohexylamine (108-91-8,157973-60-9) → 4-((4-(cyclohexylamino)-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile (1350829-09-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 70 - 80 ℃;

DOI:10.1007/s00044-011-9849-0

upstream raw materials:

4-hydroxy-1-methyl-2(1H)-quinolone

4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzonitrile

4-Aminobenzonitrile

Downstream raw materials:

4-{4-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yloxy)-6-[4-(4-trifluoromethylphenyl)piperazin-1-yl]-[1,3,5]triazin-2-ylamino}benzonitrile

4-[4-[4-(4-fluorophenyl)piperazin-1-yl]-6-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yloxy)-[1,3,5]triazin-2-ylamino]benzonitrile

4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yloxy)-[1,3,5]triazin-2-ylamino]benzonitrile

4-{4-(1-methyl-2-oxo-1,2-dihydroquinolin-4-yloxy)-6-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-[1,3,5]triazin-2-ylamino}benzonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1326231-32-6 4-((4-chloro-6-((1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)-1,3,5-triazin-2-yl)amino)benzonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send