5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Base Information

Chemical Name:5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine
CAS No.:159312-23-9
Molecular Formula:C₃₄H₃₆N₂O₇
Molecular Weight:584.669
Hs Code.:

Synonyms:5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Suppliers and Price of 5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

There total 8 articles about 5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 159312-22-8
5'-O-(p-monomethoxytrityl)-2'-O-phenoxythiocarbonyl-3'-deoxy-3'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

: 159312-23-9
5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Guidance literature:: With tri-n-butyl-tin hydride; In toluene; at 95 ℃; for 3h;
DOI:10.1016/S0040-4020(01)90437-5

Reference yield:

: 159312-11-5
5'-O-(p-monomethoxytrityl)-2',3'-secoribothymidine

: 159312-23-9
5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Guidance literature:: Multi-step reaction with 6 steps

1: 23 percent / pyridine / Ambient temperature

2: DCC, dichloroacetic acid / dimethylsulfoxide / 2 h

3: tetrahydrofuran

4: 84 percent / NH₄F / methanol

5: 86 percent / DMAP, pyridine / acetonitrile / 0.5 h

6: 72 percent / Bu₃SnH / toluene / 3 h / 95 °C

With pyridine; dichloro-acetic acid; dmap; ammonium fluoride; tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)90437-5

Reference yield:

: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-propionaldehyde

: 159312-23-9
5'-O-(p-monomethoxytrityl)-2',3'-dideoxy-3'-C-carbethoxymethylene-ribothymidine

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / ethanol

2: 23 percent / pyridine / Ambient temperature

3: DCC, dichloroacetic acid / dimethylsulfoxide / 2 h

4: tetrahydrofuran

5: 84 percent / NH₄F / methanol

6: 86 percent / DMAP, pyridine / acetonitrile / 0.5 h

7: 72 percent / Bu₃SnH / toluene / 3 h / 95 °C

With pyridine; dichloro-acetic acid; dmap; ammonium fluoride; sodium tetrahydroborate; tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)90437-5