N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine

Base Information

• Chemical Name: N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine
• CAS No.: 937276-32-9
• Molecular Formula: C₂₄H₃₁N₅O₉
• Molecular Weight: 533.538

Synonyms:N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine

Chemical Property of N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine

There total 6 articles about N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonyl-hydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycinate (937276-18-1) → N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine (937276-32-9)

Guidance literature:

With potassium hydroxide; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.02.102

Reference yield:

Nα-(benzyloxycarbonyl)-Nβ-(tert-butoxycarbonyl)-Nβ-(2-hydroxyethyl)hydrazide (937276-26-1) → N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine (937276-32-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.83 h / 20 °C

1.2: methyl tert-butyl ether; NaHCO₃; Na₂S₂O₃ / CH₂Cl₂; H₂O / 0.42 h / 20 °C

2.1: 43 percent / diisopropylethylamine; NaBH₃CN; ZnCl₂ / methanol / 25 h

3.1: 75 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; diisopropylethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 22 h / 20 °C

4.1: 95 percent / aq. KOH / 1 h / 20 °C

With potassium hydroxide; sodium cyanoborohydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; zinc(II) chloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.02.102

Reference yield:

Nα-(benzyloxycarbonyl)-Nβ-(tert-butoxycarbonyl)-Nβ-(formylmethyl)hydrazide (937276-27-2) → N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine (937276-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 43 percent / diisopropylethylamine; NaBH₃CN; ZnCl₂ / methanol / 25 h

2: 75 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; diisopropylethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 22 h / 20 °C

3: 95 percent / aq. KOH / 1 h / 20 °C

With potassium hydroxide; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; zinc(II) chloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.02.102

upstream raw materials:

methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycinate

N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]glycinate

Downstream raw materials:

methyl N-[2-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycyl]aminoethyl-N-[(thymin-1-yl)acetyl]glycinate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 937276-32-9 N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonylhydrazino)ethyl]-N-[(thymin-1-yl)acetyl]glycine

Send

Send

Metric Ton KG G Pound L ML

Send

Send