2,4-DIFLUORO-2''-NITRODIPHENYLAMINE

Base Information

• Chemical Name: 2,4-DIFLUORO-2''-NITRODIPHENYLAMINE
• CAS No.: 500302-20-5
• Molecular Formula: C12H8F2N2O2
• Molecular Weight: 250.205
• Hs Code.: 2921420090
• Mol file: 500302-20-5.mol

Synonyms:2,4-DIFLUORO-2''-NITRODIPHENYLAMINE

Chemical Property of 2,4-DIFLUORO-2''-NITRODIPHENYLAMINE

Chemical Property:

• Boiling Point: 315.1±42.0 °C(Predicted)
• PKA: -4.52±0.50(Predicted)
• PSA: 57.85000
• Density: 1.423±0.06 g/cm3(Predicted)
• LogP: 4.21280
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

2,4-Difluoro-2''-nitrodiphenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIFLUORO-2''-NITRODIPHENYLAMINE

There total 3 articles about 2,4-DIFLUORO-2''-NITRODIPHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

→ 2,4-difluoro-N-(2-nitrophenyl)aniline (500302-20-5)

Guidance literature:

With sodium t-butanolate; In toluene; for 1h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In toluene; at 60 ℃; Inert atmosphere;

Reference yield: 68.0%

2,4-difluorophenylamine (367-25-9,76563-56-9) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2,4-difluoro-N-(2-nitrophenyl)aniline (500302-20-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 18 - 25 ℃; for 1h;

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) + 2-Chloronitrobenzene (88-73-3) → 2,4-difluoro-N-(2-nitrophenyl)aniline (500302-20-5)

Guidance literature:

2-Chloronitrobenzene; With potassium carbonate; at 120 ℃;

2,4-difluorophenylamine; at 165 ℃; for 2h;

DOI:10.1016/j.bmcl.2016.11.026

upstream raw materials:

2,4-difluorophenylamine

ortho-nitrofluorobenzene

2-Chloronitrobenzene

Downstream raw materials:

N¹-(2,4-difluorophenyl)benzene-1,2-diamine