di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Base Information

Chemical Name:di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate
CAS No.:298211-10-6
Molecular Formula:C₂₄H₃₄Br₂F₂N₂O₅
Molecular Weight:628.349
Hs Code.:

Synonyms:di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

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Chemical Property of di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Chemical Property:

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Technology Process of di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

There total 5 articles about di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 298211-19-5
2-{4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester

: 298211-10-6
di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Guidance literature:: With lithium bromide; In acetone; Heating;
DOI:10.1021/jm0502182

Reference yield:

: 298211-18-4
2-{4-[bis-(2-hydroxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester

: 298211-10-6
di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; DMAP / CH₂Cl₂ / 16 h / cooling

2: 0.87 g / LiBr / acetone / Heating

With dmap; triethylamine; lithium bromide; In dichloromethane; acetone;
DOI:10.1021/jm0502182

Reference yield:

: 134227-45-5
3,4,5-trifluorobenzonitrile

: 298211-10-6
di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: 50 °C

2: 87 percent / aq. NaOH / ethanol

3: triethylamine; diethylcyanophosphonate / dimethylformamide / 72 h

4: Et₃N; DMAP / CH₂Cl₂ / 16 h / cooling

5: 0.87 g / LiBr / acetone / Heating

With dmap; sodium hydroxide; diethyl cyanophosphonate; triethylamine; lithium bromide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0502182