N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Base Information

• Chemical Name: N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide
• CAS No.: 147911-92-0
• Molecular Formula: C₄₃H₅₀N₁₀O₈
• Molecular Weight: 834.932

Synonyms:N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Chemical Property of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

There total 9 articles about N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pyrimidoblamic acid (75452-30-1) + erythro-N?-Triphenylmethyl-β-hydroxy-L-histidinmethylester (142582-33-0) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (147911-92-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 25 ℃; for 72h;

Reference yield:

Boc-Dap(NH2)-CONH2 (75452-33-4) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (147911-92-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / mol.-sieves 4 Angstroem / acetonitrile / 6 h / 25 °C

2: tetrahydrofuran / 12 h / 0 °C

3: 95 percent / Bu₃SnH, azobisisobutyronitrile / benzene / 0.75 h / 80 °C

4: 85 percent / NH₃ / ethanol / 1 h / 0 °C

5: 95 percent / LiOH / tetrahydrofuran; H₂O; methanol / 1 h / 0 °C

6: 68 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt / tetrahydrofuran; dimethylformamide / 55 h / 25 °C

With lithium hydroxide; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; ammonia; tri-n-butyl-tin hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;

Reference yield:

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (75624-28-1) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (147911-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / LiOH / tetrahydrofuran; H₂O; methanol / 1 h / 0 °C

2: 68 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt / tetrahydrofuran; dimethylformamide / 55 h / 25 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

pyrimidoblamic acid

erythro-N^?-Triphenylmethyl-β-hydroxy-L-histidinmethylester

Boc-Dap(NH₂)-CONH₂

N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Downstream raw materials:

C₆₅H₈₂N₁₆O₁₃S₃

(2S,3R)-2-({6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carbonyl}-amino)-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 147911-92-0 N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histydyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send