Technology Process of (S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N,4-dimethylpentanamide
There total 5 articles about (S)-N-benzyl-2-(N-(but-3-en-1-yl)phenylsulfonamido)-N,4-dimethylpentanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
DOI:10.1021/ol103105q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C
2.2: 6 h / 60 °C
3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 °C / Inert atmosphere
With
lithium hydroxide monohydrate; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; caesium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol103105q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 °C / Inert atmosphere
With
lithium hydroxide monohydrate; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol103105q