2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

Base Information

Chemical Name:2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine
CAS No.:116387-37-2
Molecular Formula:C₂₅H₂₆N₄O₄
Molecular Weight:446.506
Hs Code.:

Synonyms:2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

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Chemical Property of 2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

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Technology Process of 2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

There total 4 articles about 2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 116387-22-5
2-pivaloylamino-6-bromo-4(3H)-pyrido[2,3-d]pyrimidinone

: 111291-97-5
4-ethynylbenzoic acid tert-butyl ester

: 116387-37-2
2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

Guidance literature:: With copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride; In acetonitrile; for 2.5h; Heating;
DOI:10.1021/jo00276a023

Reference yield:

: 59247-47-1
tert-butyl-4-bromobenzoate

: 116387-37-2
2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium acetate, triphenylphosphine, triethylamine / 16 h / 100 °C

2: K₂CO₃ / methanol / 3 h / Ambient temperature

3: 69 percent / triphenylphosphine, triethylamine, palladium chloride, cuprous iodide / acetonitrile / 2.5 h / Heating

With copper(l) iodide; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; palladium dichloride; In methanol; acetonitrile;
DOI:10.1021/jo00276a023

Reference yield:

: 111291-96-4
tert-butyl 4-<(trimethylsilyl)ethynyl>benzoate

: 116387-37-2
2-(pivaloylamino)-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / methanol / 3 h / Ambient temperature

2: 69 percent / triphenylphosphine, triethylamine, palladium chloride, cuprous iodide / acetonitrile / 2.5 h / Heating

With copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; palladium dichloride; In methanol; acetonitrile;
DOI:10.1021/jo00276a023