(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester
CAS No.:302600-51-7
Molecular Formula:C₃₀H₄₁NO₅Si
Molecular Weight:523.745
Hs Code.:

Synonyms:(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

There total 5 articles about (R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-((2E,7E)-(5S,6R)-5-Methoxymethoxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

: 302600-51-7
(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In tert-butyl alcohol; for 6h; Heating;
DOI:10.1016/S0040-4020(01)00339-8

Reference yield:

: 162473-70-3
(E)-(3S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-6-phenyl-hex-5-en-3-ol

: 302600-51-7
(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: iPr₂NEt / CH₂Cl₂ / 10 h

2.1: 130 mg / TBAF / tetrahydrofuran / 3 h

3.1: Dess-Martin periodinane / CH₂Cl₂ / 0 °C

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: tetrahydrofuran / 0.33 h / 0 °C

5.1: 120 mg / PPTS / 2-methyl-propan-2-ol / 6 h / Heating

With tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 3.1: Dess-Martin oxidation / 4.2: Horner-Emmons reaction;
DOI:10.1016/S0040-4020(01)00339-8

Reference yield:

: (E)-(3S,4R)-3-Methoxymethoxy-4-methyl-6-phenyl-hex-5-enal

: 302600-51-7
(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 0 °C

1.2: tetrahydrofuran / 0.33 h / 0 °C

2.1: 120 mg / PPTS / 2-methyl-propan-2-ol / 6 h / Heating

With pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; tert-butyl alcohol; 1.2: Horner-Emmons reaction;
DOI:10.1016/S0040-4020(01)00339-8