N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

Base Information

Chemical Name:N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide
CAS No.:1283595-17-4
Molecular Formula:C₂₅H₃₂N₄O₃
Molecular Weight:436.554
Hs Code.:

Synonyms:N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

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Chemical Property of N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

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Technology Process of N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

There total 6 articles about N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: C₂₁H₂₄BrN₃O₂

: 40499-83-0,83220-72-8,100243-39-8,2799-21-5
(3R)-pyrrolidinol

: 1283595-17-4
N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.132

Reference yield:

: 135680-03-4
N-{4-[(4-aminobenzyl)phenyl]}carbamic acid 1,1-dimethylethyl ester

: 1283595-17-4
N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere

2: tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

3: hydrogenchloride / methanol; ethyl acetate / Inert atmosphere

4: pyridine; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere

5: potassium carbonate / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2010.12.132

Reference yield:

: 1283594-44-4
N-{4-[4-(2-bromoacetylamino)benzyl]phenyl}carbamic acid 1,1-dimethylethyl ester

: 1283595-17-4
N-{4-[4-({2-[(3R)-3-hydroxy-1-pyrrolidinyl]acetyl}amino)benzyl]phenyl}-2-(1-pyrrolidinyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

2: hydrogenchloride / methanol; ethyl acetate / Inert atmosphere

3: pyridine; dmap / dichloromethane / 3 h / 25 °C / Inert atmosphere

4: potassium carbonate / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2010.12.132