N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

Base Information

Chemical Name:N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide
CAS No.:1425046-39-4
Molecular Formula:C₂₀H₁₇ClN₆O₃S
Molecular Weight:456.912
Hs Code.:

Synonyms:N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

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Chemical Property of N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

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Technology Process of N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

There total 5 articles about N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1425046-39-4
N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate; hydrogenchloride / 20 °C

2: pyridine

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 4 h / Reflux; Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere; Reflux

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin(II) chloride dihdyrate; potassium acetate; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 4: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.06.052

Reference yield:

: 1010120-53-2
N-(6-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide

: C₁₈H₂₂BClN₂O₄S

: 1425046-39-4
N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; water; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2013.06.052

Reference yield:

: 1162680-94-5
N-(5-bromo-2-chloropyridin-3-yl)-4-methylbenzenesulfonamide

: 1425046-39-4
N-(6-(6-chloro-5-(4-methylphenylsulfonamido)pyridin-3-yl)-[1,2,4]triazolo[1,5-a pyridin-2-yl])acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 4 h / Reflux; Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.06.052