N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

Base Information

Chemical Name:N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester
CAS No.:85918-27-0
Molecular Formula:C₄₂H₄₇N₅O₁₀
Molecular Weight:781.863
Hs Code.:

Synonyms:N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

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Chemical Property of N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

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Technology Process of N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

There total 5 articles about N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3556-56-7
4-nitrophenyl N-[(benzyloxy)carbonyl]-L-tyrosinate

: 764602-93-9
(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-3-ethoxy-propionic acid benzyl ester

: 85918-27-0
N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 48h; Ambient temperature; pH=7.5;
DOI:10.1016/S0040-4020(01)88549-5

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 85918-27-0
N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1 ) N-methyl-morpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 10 min; 2.) THF, -5 deg C, 3 h, 20 deg C, 1 h

2: 2.) N-methyl-morpholine / 1.) CF₃COOH, CH₂Cl₂, 20 deg C, 45 min; 2.) DMF

3: 1.) DMF, -4 deg C, 15 min, rt, 20 min; 2.) rt, 15 min

4: 1N HCl / acetic acid / 1 h

5: 75 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature; pH=7.5

With 4-methyl-morpholine; hydrogenchloride; triethylamine; isobutyl chloroformate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88549-5

Reference yield:

: 85918-29-2
N-t-Butyloxycarbonyl-phenylalanyl-(O-ethyl)serine benzyl ester

: 85918-27-0
N-carbobenzoxy-tyrosyl-glycyl-glycyl-phenylalanyl-(O-ethyl)serine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) N-methyl-morpholine / 1.) CF₃COOH, CH₂Cl₂, 20 deg C, 45 min; 2.) DMF

2: 1.) DMF, -4 deg C, 15 min, rt, 20 min; 2.) rt, 15 min

3: 1N HCl / acetic acid / 1 h

4: 75 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature; pH=7.5

With 4-methyl-morpholine; hydrogenchloride; triethylamine; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88549-5