[trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

Base Information

Chemical Name:[trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile
CAS No.:1607591-64-9
Molecular Formula:C₁₈H₂₀N₄S
Molecular Weight:324.45
Hs Code.:

Synonyms:[trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

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Chemical Property of [trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

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Technology Process of [trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

There total 10 articles about [trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1607589-86-5
{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile

: 115-80-0
Triethyl orthopropionate

: 1607591-64-9
[trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

Guidance literature:: With acetic acid; at 120 ℃; for 0.5h;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607591-64-9
[trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: acetic acid / 0.5 h / 120 °C

With palladium 10% on activated carbon; hydrogen; tetrabutylammonium nitrate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 104515-05-1,905735-40-2
6-nitrothieno[3,2-b]pyridin-7-ol

: 1607591-64-9
[trans-4-(2-ethyl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / Reflux

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: acetic acid / 0.5 h / 120 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; isopropyl alcohol;