N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

Base Information

Chemical Name:N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide
CAS No.:803728-37-2
Molecular Formula:C₂₉H₂₉F₂NO₈S
Molecular Weight:589.614
Hs Code.:

Synonyms:N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

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Chemical Property of N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

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Technology Process of N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

There total 5 articles about N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 803728-36-1
N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) methane sulfonamide

: 803728-37-2
N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

Guidance literature:: With sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 ℃; for 2.75h;
DOI:10.1021/ol048249z

Reference yield:

: 14002-90-5
4,7-dimethyl-coumarin

: 803728-37-2
N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / NBS; (PhCO₂)2 / benzene / 16 h / Heating

2: 76 percent / Na₂SO₃ / ethanol; H₂O / 5 h / Heating

3: SOCl₂ / benzene; dimethylformamide / 5 h / 86 °C

4: 3.70 g / DMAP / tetrahydrofuran / Heating

5: 53 percent / N-fluorobenzenesulfonimide; NaHMDS / tetrahydrofuran / 2.75 h / -78 °C

With dmap; N-Bromosuccinimide; thionyl chloride; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; sodium sulfite; dibenzoyl peroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol048249z

Reference yield:

: 53878-05-0
7-bromomethyl-4-methylcoumarin

: 803728-37-2
N,N-bis(2,4-dimethoxybenzyl) 7-(4-methylcoumarin) difluoromethane sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Na₂SO₃ / ethanol; H₂O / 5 h / Heating

2: SOCl₂ / benzene; dimethylformamide / 5 h / 86 °C

3: 3.70 g / DMAP / tetrahydrofuran / Heating

4: 53 percent / N-fluorobenzenesulfonimide; NaHMDS / tetrahydrofuran / 2.75 h / -78 °C

With dmap; thionyl chloride; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; sodium sulfite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol048249z