3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

Base Information

Chemical Name:3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene
CAS No.:1441047-08-0
Molecular Formula:C₃₆H₄₀N₂O₄
Molecular Weight:564.725
Hs Code.:

Synonyms:3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

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Chemical Property of 3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

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Technology Process of 3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

There total 4 articles about 3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.81%

: 1,3-phenyldiacetic acid

: 851983-85-2
Galeterone

: 1441047-08-0
3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

Guidance literature:: With pyridine; dmap; 2-methyl-6-nitrobenzoic anhydride; In tetrahydrofuran; at 20 ℃; for 2h; Reflux;
DOI:10.1021/jm400048v

Reference yield: 39.81%

: 1441047-08-0
3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

Guidance literature:: With dmap; 2-methyl-6-nitrobenzoic anhydride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 851895-78-8
3-β-acetoxy-17-(1H-benzimidazol-1-yl)-16-formyl-androsta-5,16-diene

: 1441047-08-0
3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon / benzonitrile / 5 h / Reflux; Inert atmosphere

2: potassium hydroxide; methanol / 1.5 h / Inert atmosphere

3: 2-methyl-6-nitrobenzoic anhydride; dmap; pyridine / tetrahydrofuran / 2 h / 20 °C / Reflux

With pyridine; methanol; dmap; palladium 10% on activated carbon; 2-methyl-6-nitrobenzoic anhydride; potassium hydroxide; In tetrahydrofuran; benzonitrile;
DOI:10.1021/jm400048v