4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine

Base Information

• Chemical Name: 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine
• CAS No.: 301225-86-5
• Molecular Formula: C₁₈H₂₆FNO₂S
• Molecular Weight: 339.474
• Mol file: 301225-86-5.mol

Synonyms:4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine

Chemical Property of 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine

There total 3 articles about 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorothiophenol (371-42-6) + tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate (89151-46-2) → 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine (301225-86-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(02)00829-6

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine (301225-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂

2: I₂; PPh₃; imidazole / diethyl ether; acetonitrile

3: NaH / tetrahydrofuran

With 1H-imidazole; iodine; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/S0960-894X(02)00829-6

Reference yield:

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester (89151-44-0) → 4-(2-((4-fluorophenyl)thio)-1-ethyl)-1-tert-butoxycarbonyl-piperidine (301225-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂; PPh₃; imidazole / diethyl ether; acetonitrile

2: NaH / tetrahydrofuran

With 1H-imidazole; iodine; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile;

DOI:10.1016/S0960-894X(02)00829-6

upstream raw materials:

4-Fluorothiophenol

tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate

di-tert-butyl dicarbonate

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-(2-((4-fluorophenyl)sulfonyl)-1-ethyl)piperidine