methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate

Base Information

Chemical Name:methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate
CAS No.:1351984-92-3
Molecular Formula:C₃₇H₆₈O₆Si₂
Molecular Weight:665.114
Hs Code.:

Synonyms:methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate

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Technology Process of methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate

There total 1 articles about methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911-40-0
7-ketodeoxycholic acid

: 1351984-92-3
methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 2 h / Heating

2: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

With 1H-imidazole; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; 2: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2011.10.108

Reference yield: 90.0%

: 1351984-92-3
methyl 3α,12α-di(tert-butyldimethylsilyloxy)-7-oxo-8-oxa-B-homo-cholan-24-oate

: 3α,12α-di(tert-butyldimethylsilyloxy)-7,8-seco-5β-cholan-7,8α,24-triol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.steroids.2013.03.004