(-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

Base Information

Chemical Name:(-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane
CAS No.:249622-03-5
Molecular Formula:C₂₅H₃₅NO₄
Molecular Weight:413.557
Hs Code.:

Synonyms:(-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

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Chemical Property of (-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

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Technology Process of (-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

There total 4 articles about (-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 249622-02-4
(-)-(1R,2R)-2-methoxy-1-(2-tosyloxyethoxy)-1,2-diphenylethane

: C₈H₁₆NO₂^(1-)*Na⁽¹⁺⁾

: 249622-03-5
(-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

Guidance literature:: In N,N-dimethyl-formamide; at 75 ℃; for 20h;
DOI:10.1016/S0040-4020(99)00644-4

Reference yield:

: 115889-24-2
(1R,2R)-2-methoxy-1,2-diphenylethan-1-ol

: 249622-03-5
(-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 1 h / 80 °C

1.2: 80 percent / dimethylformamide / 20 h / 80 °C

2.1: 91 percent / conc. HCl / methanol / 2 h / 20 °C

3.1: 80 percent / pyridine / 20 h / 0 °C

4.1: 70 percent / dimethylformamide / 20 h / 75 °C

With hydrogenchloride; sodium hydride; In pyridine; methanol; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Tosylation / 4.1: Substitution;
DOI:10.1016/S0040-4020(99)00644-4

Reference yield:

: 249622-00-2
(-)-(1R,2R)-2-methoxy-1-(2-trityloxyethoxy)-1,2-diphenylethane

: 249622-03-5
(-)-(1R,2R)-1-[2-(N-Boc-N-isopropylamino)ethoxy]-2-methoxy-1,2-diphenylethane

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / conc. HCl / methanol / 2 h / 20 °C

2: 80 percent / pyridine / 20 h / 0 °C

3: 70 percent / dimethylformamide / 20 h / 75 °C

With hydrogenchloride; In pyridine; methanol; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Tosylation / 3: Substitution;
DOI:10.1016/S0040-4020(99)00644-4