N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

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Chemical Name:N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate
CAS No.:1061749-16-3
Molecular Formula:C₂HF₃O₂*C₂₄H₂₉FN₆O₃
Molecular Weight:582.555
Hs Code.:

Synonyms:N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

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Chemical Property of N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

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Technology Process of N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

There total 7 articles about N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061749-11-8
N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-fluoro-5-((S)-pyrrolidin-3-yloxy)-phenyl]-pyrimidin-4-yl}-acetamide

: 76-05-1
trifluoroacetic acid

: 6482-24-2
2-Bromoethyl methyl ether

: 1061749-16-3
N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

Guidance literature:: N-{2-(3,5-dimethyl-pyrazol-1-yl)-6-[3-fluoro-5-((S)-pyrrolidin-3-yloxy)-phenyl]-pyrimidin-4-yl}-acetamide; 2-Bromoethyl methyl ether; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

trifluoroacetic acid; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1014720-95-6
6-chloro-2-(3,5-dimethyl-pyrazol-1-yl)-pyrimidin-4-ylamine

: 1061749-16-3
N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 20 - 90 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 100 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

4: hydrogenchloride / diethyl ether / 1 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

With hydrogenchloride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1014720-89-8
N-[6-chloro-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide

: 1061749-16-3
N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-{3-fluoro-5-[(S)-(2-methoxy-ethyl)-pyrrolidin-3-yloxy]-phenyl}-pyrimidin-4-yl)-acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 100 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

3: hydrogenchloride / diethyl ether / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

With hydrogenchloride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;