8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

Base Information

Chemical Name:8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine
CAS No.:1254980-15-8
Molecular Formula:C₂₃H₂₄F₄N₄
Molecular Weight:432.464
Hs Code.:

Synonyms:8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

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Chemical Property of 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

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Technology Process of 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

There total 5 articles about 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1254982-05-2
7-((methylsulfonyloxy)methyl)-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 180161-17-5
4-(2-fluorophenyl)piperidine

: 1254980-15-8
8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 4h; Sealed tube;
DOI:10.1021/acs.jmedchem.6b00913

Reference yield:

: 1254982-04-1
7-(hydroxymethyl)-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254980-15-8
8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 100 °C / Sealed tube

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00913

Reference yield:

: 1254981-30-0
7-chloro-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254980-15-8
8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2-fluorophenyl)-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,4-dioxane / 0.22 h / 150 °C / Microwave irradiation

2: osmium(VIII) oxide; sodium periodate / tert-butyl alcohol; water; 1,4-dioxane / 2 h / 20 °C

3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 100 °C / Sealed tube

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00913