N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

Base Information

Chemical Name:N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine
CAS No.:1358742-16-1
Molecular Formula:C₂₄H₃₄N₄O₂
Molecular Weight:410.56
Hs Code.:

N<sub>1</sub>,N<sub>2</sub>-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

Synonyms:N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

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Chemical Property of N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

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Technology Process of N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

There total 5 articles about N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1358742-12-7
N₁,N₂-bis(2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)oxalamide

: 1358742-16-1
N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

Guidance literature:: N₁,N₂-bis(2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)oxalamide; With lithium aluminium tetrahydride; In tetrahydrofuran; Inert atmosphere; Cooling with ice; Reflux;

With water; sodium hydroxide; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.11.015

Reference yield:

: 1358742-03-6
(S)-(1-(2-aminophenyl)pyrrolidin-2-yl)methanol

: 1358742-16-1
N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Cooling with ice; Reflux

2.2: Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2011.11.015

Reference yield:

: [(2S)-1-(2-nitrophenyl)pyrrolidin-2-yl]methanol

: 1358742-16-1
N₁,N₂-bis((2-(S)-2-(hydroxymethyl)pyrrolidin-1-yl)phenyl)ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(ll) chloride / ethanol / 3 h / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Cooling with ice; Reflux

3.2: Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetasy.2011.11.015