3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

Base Information

Chemical Name:3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine
CAS No.:1350457-43-0
Molecular Formula:C₂₇H₃₀ClN₃
Molecular Weight:432.008
Hs Code.:

Synonyms:3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

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Chemical Property of 3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

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Technology Process of 3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

There total 8 articles about 3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350460-25-1
1-(3-benzyl-2,3,4,4a,5,6-hexahydropyrazino[1,2-a][1,5]benzodiazepin-7(1H)-yl)-2-(4-chlorophenyl)ethanone

: 1350457-43-0
3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

Guidance literature:: 1-(3-benzyl-2,3,4,4a,5,6-hexahydropyrazino[1,2-a][1,5]benzodiazepin-7(1H)-yl)-2-(4-chlorophenyl)ethanone; With alane-N,N-dimethylethylamine complex; In tetrahydrofuran; toluene; at 20 ℃; for 12.5h; Inert atmosphere; Cooling with ice;

With methanol; In tetrahydrofuran; toluene;

Reference yield:

: 1350460-07-9
2-(4-benzyl-1-(2-nitrophenyl)piperazin-2-yl)acetic acid

: 1350457-43-0
3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / platinum on carbon / methanol / 18 h / 760.05 Torr

1.2: 3 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / 20 - 60 °C / Inert atmosphere

2.2: Cooling with ice

3.1: dichloromethane / 2 h / 20 °C

4.1: alane-N,N-dimethylethylamine complex / toluene; tetrahydrofuran / 12.5 h / 20 °C / Inert atmosphere; Cooling with ice

With lithium aluminium tetrahydride; alane-N,N-dimethylethylamine complex; hydrogen; platinum on carbon; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1350457-43-0
3-benzyl-7-[2-(4-chlorophenyl)ethyl]-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 18-crown-6 ether / acetonitrile; water / 29 h / 100 °C / Inert atmosphere

1.2: pH ~ 4

2.1: hydrogen / platinum on carbon / methanol / 18 h / 760.05 Torr

2.2: 3 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / 20 - 60 °C / Inert atmosphere

3.2: Cooling with ice

4.1: dichloromethane / 2 h / 20 °C

5.1: alane-N,N-dimethylethylamine complex / toluene; tetrahydrofuran / 12.5 h / 20 °C / Inert atmosphere; Cooling with ice

With lithium aluminium tetrahydride; alane-N,N-dimethylethylamine complex; hydrogen; potassium carbonate; 18-crown-6 ether; platinum on carbon; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;