5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

Base Information

Chemical Name:5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline
CAS No.:1256496-97-5
Molecular Formula:C₂₅H₂₂ClN₃O₅S
Molecular Weight:511.986
Hs Code.:

Synonyms:5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

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Chemical Property of 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

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Technology Process of 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

There total 7 articles about 5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1256496-95-3
C₂₅H₂₁ClN₂O₃

: 1256496-97-5
5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

Guidance literature:: With sulphamoyl chloride; In ISOPROPYLAMIDE; for 3h;
DOI:10.3390/molecules15117971

Reference yield:

: 1256496-85-1
C₁₀H₉N₃O₃

: 1256496-97-5
5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

Guidance literature:: Multi-step reaction with 4 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / Reflux

2: sodium hydroxide / methanol / 1 h / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

4: sulphamoyl chloride / ISOPROPYLAMIDE / 3 h

With sulphamoyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; ISOPROPYLAMIDE; N,N-dimethyl-formamide;
DOI:10.3390/molecules15117971

Reference yield:

: 21598-06-1
5-hydroxyindole-2-carboxylic acid

: 1256496-97-5
5-benzyloxy-1-chloromethyl-1,2-dihydro-3-[(5-sulfamoyloxy-1H-indol-2-yl)carbonyl]indoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

2: sulphamoyl chloride / ISOPROPYLAMIDE / 3 h

With sulphamoyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ISOPROPYLAMIDE; N,N-dimethyl-formamide;
DOI:10.3390/molecules15117971