(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS No.:870001-87-9
Molecular Formula:C₃₅H₅₃N₃O₁₆Si
Molecular Weight:799.902
Hs Code.:

(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Synonyms:(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Chemical Property of (2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Technology Process of (2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

There total 17 articles about (2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 870001-64-2
methyl (methyl 4-O-[2-azido-6-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-levulinoyl-4-O-(p-methoxybenzyl)-α-D-glucopyranosyl]-2-O-acetyl-3-O-[2-(trimethylsilyl)ethoxymethyl]-α-D-glucopyranosyluronate)

: 870001-87-9
(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol052130o

Reference yield:

: p-tolyl 3-O-acetyl-1,2-deoxy-4,6-O-(p-methoxybenzylidene)-2-phthalimido-1-thio-β-D-glucopyranoside

: 870001-87-9
(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 84 percent / Bu₂BOTf; BH₃*THF / tetrahydrofuran; CH₂Cl₂ / 1.5 h / -20 - -5 °C

2.1: 88 percent / imidazole / dimethylformamide / 24 h / 20 °C

3.1: NaOMe / CH₂Cl₂; methanol / 4 h / 20 °C

4.1: ethylenediamine / butan-1-ol / 12 h / 100 °C

5.1: 0.600 g / CuSO₄*5H₂O; potassium carbonate; TfN₃ / methanol; H₂O / 48 h / 20 °C

6.1: 90 percent / DCC; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

7.1: N-benzenesulfinyl piperidine; Tf₂O; molecular sieves 4 Angstroem / DTBMP / CH₂Cl₂ / -60 °C

7.2: 25 percent / CH₂Cl₂ / 20 h / -60 - 20 °C

8.1: 80 percent / TBAF; HF*pyridine / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; dmap; borane-THF; 1-benzenesulfinyl piperidine; trifluoromethylsulfonic anhydride; 4 A molecular sieve; di-n-butylboryl trifluoromethanesulfonate; triflic azide; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; pyridine hydrogenfluoride; copper(II) sulfate; ethylenediamine; dicyclohexyl-carbodiimide; 2,6-di-tert-butyl-4-methylpyridine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/ol052130o

Reference yield:

: 870001-81-3
Acetic acid (2S,3R,4R,5S,6R)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-p-tolylsulfanyl-tetrahydro-pyran-4-yl ester

: 870001-87-9
(2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-6-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / imidazole / dimethylformamide / 24 h / 20 °C

2.1: NaOMe / CH₂Cl₂; methanol / 4 h / 20 °C

3.1: ethylenediamine / butan-1-ol / 12 h / 100 °C

4.1: 0.600 g / CuSO₄*5H₂O; potassium carbonate; TfN₃ / methanol; H₂O / 48 h / 20 °C

5.1: 90 percent / DCC; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

6.1: N-benzenesulfinyl piperidine; Tf₂O; molecular sieves 4 Angstroem / DTBMP / CH₂Cl₂ / -60 °C

6.2: 25 percent / CH₂Cl₂ / 20 h / -60 - 20 °C

7.1: 80 percent / TBAF; HF*pyridine / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; dmap; 1-benzenesulfinyl piperidine; trifluoromethylsulfonic anhydride; 4 A molecular sieve; triflic azide; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; pyridine hydrogenfluoride; copper(II) sulfate; ethylenediamine; dicyclohexyl-carbodiimide; 2,6-di-tert-butyl-4-methylpyridine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/ol052130o