tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate
CAS No.:763111-56-4
Molecular Formula:C₂₆H₃₀N₄O₄
Molecular Weight:462.549
Hs Code.:

Synonyms:tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

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Chemical Property of tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

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Technology Process of tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

There total 5 articles about tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 420846-72-6
3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

: 112275-50-0
tert-butyl 1,4-diazepine-1-carboxylate

: 763111-56-4
tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm8001263

Reference yield:

: 3-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

: 763111-56-4
tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / Heating

2: Hunigs base / N,N-dimethyl-acetamide

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2005.10.081

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 763111-56-4
tert-butyl 4-[3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methoxide / methanol / Heating

2: hydrazine hydrate / Heating

3: Hunigs base / N,N-dimethyl-acetamide

With sodium methylate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2005.10.081