N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Base Information

Chemical Name:N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea
CAS No.:852660-76-5
Molecular Formula:C₃₁H₄₃FN₄O₃
Molecular Weight:538.706
Hs Code.:

Synonyms:N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

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Chemical Property of N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

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Technology Process of N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

There total 25 articles about N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405905-06-8
phenyl (3-acetylphenyl)carbamate

: 852660-82-3
C₂₂H₃₆FN₃O

: 852660-75-4
N-(3-acetylphenyl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

: 852660-76-5
N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 852660-75-4
N-(3-acetylphenyl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

: 852660-76-5
N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0 °C

1.2: 0.5 h

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4.1: dichloromethane / 0.5 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride; water / acetonitrile

6.1: ethanol; dichloromethane / 0.5 h

6.2: 48 h / 20 °C

7.1: triethylamine / dichloromethane / 16 h / 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr

9.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-75-4
N-(3-acetylphenyl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

: 852660-76-5
N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux

5.1: dichloromethane / 0.5 h / 20 °C

5.2: 16 h / 20 °C

6.1: hydrogenchloride; water / acetonitrile

7.1: ethanol; dichloromethane / 0.5 h

7.2: 48 h / 20 °C

8.1: triethylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr

10.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; water; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;