Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate

Base Information

Chemical Name:Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate
CAS No.:528607-26-3
Molecular Formula:C11H20O3
Molecular Weight:200.2747
Hs Code.:2918199090
DSSTox Substance ID:DTXSID30449241
Mol file:528607-26-3.mol

Synonyms:528607-26-3;Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate;DTXSID30449241;Cyclopropanecarboxylic acid,2-ethyl-2-(3-hydroxypropyl)-,ethyl ester(9ci)

Suppliers and Price of Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate

Chemical Property:

PSA：46.53000
LogP:1.73830
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:200.14124450
Heavy Atom Count:14
Complexity:203

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1(CC1C(=O)OCC)CCCO

Technology Process of Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate

There total 6 articles about Ethyl 2-ethyl-2-(3-hydroxypropyl)cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026026-03-8
2-(3-benzyloxy-propyl)-2-ethyl-cyclopropanecarboxylic acid ethyl ester

: 528607-26-3
2-(3-hydroxypropyl)-2-ethylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: With hydrogen; 5percent Pd/C; In ethanol; dichloromethane; ethyl acetate; at 18 ℃; for 22h; under 760.051 Torr;
DOI:10.1039/b209992f

Reference yield:

: 2955-62-6
methyl 4-oxohexanoate

: 528607-26-3
2-(3-hydroxypropyl)-2-ethylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaHMDS / tetrahydrofuran / 1.5 h / 18 °C

1.2: 30 percent / tetrahydrofuran / 15 h / 18 °C

2.1: 57 percent / LiAlH₄ / diethyl ether / 1.5 h

3.1: 70 percent / NaH; NaI / dimethylformamide / 18 h / 18 °C

4.1: Rh₂(OAc)4 / CH₂Cl₂ / 0.5 h / 18 °C

5.1: 210 mg / H₂ / 5percent Pd/C / CH₂Cl₂; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr

With lithium aluminium tetrahydride; hydrogen; sodium hexamethyldisilazane; sodium hydride; sodium iodide; dirhodium tetraacetate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.2: Wittig reaction;
DOI:10.1039/b209992f

Reference yield:

: 13064-28-3
methyl 4-nitrohexanoate

: 528607-26-3
2-(3-hydroxypropyl)-2-ethylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / aq. NaHCO₃; K₂CO₃; Oxone / acetone / 29 h / 18 °C

2.1: NaHMDS / tetrahydrofuran / 1.5 h / 18 °C

2.2: 30 percent / tetrahydrofuran / 15 h / 18 °C

3.1: 57 percent / LiAlH₄ / diethyl ether / 1.5 h

4.1: 70 percent / NaH; NaI / dimethylformamide / 18 h / 18 °C

5.1: Rh₂(OAc)4 / CH₂Cl₂ / 0.5 h / 18 °C

6.1: 210 mg / H₂ / 5percent Pd/C / CH₂Cl₂; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr

With Oxone; lithium aluminium tetrahydride; hydrogen; sodium hexamethyldisilazane; sodium hydride; sodium hydrogencarbonate; potassium carbonate; sodium iodide; dirhodium tetraacetate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; 1.1: Nef reaction / 2.2: Wittig reaction;
DOI:10.1039/b209992f