deuterated 3-phenylpropiolaldehyde

Base Information

• Chemical Name: deuterated 3-phenylpropiolaldehyde
• CAS No.: 31335-71-4
• Molecular Formula: C₉H₆O
• Molecular Weight: 131.138
• Mol file: 31335-71-4.mol

Synonyms:deuterated 3-phenylpropiolaldehyde

Chemical Property of deuterated 3-phenylpropiolaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of deuterated 3-phenylpropiolaldehyde

There total 6 articles about deuterated 3-phenylpropiolaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

D-3-phenylprop-2-yn-1-ol (1224466-33-4) → deuterated 3-phenylpropiolaldehyde (31335-71-4)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 12h;

DOI:10.1039/d1ra05405h

Reference yield: 70.0%

C12H11(2)HS2 → deuterated 3-phenylpropiolaldehyde (31335-71-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; water; In acetone; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.9b01003

Reference yield:

Phenylpropargyl aldehyde (2579-22-8) → deuterated 3-phenylpropiolaldehyde (31335-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 60 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -35 °C / Inert atmosphere

2.2: 8 h / -30 °C / Inert atmosphere

3.1: water; [bis(acetoxy)iodo]benzene / acetone / 0.5 h / 20 °C

With n-butyllithium; [bis(acetoxy)iodo]benzene; water; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; acetone; toluene;

DOI:10.1021/acs.orglett.9b01003

upstream raw materials:

phenylpropynoic acid ethyl ester

Phenylpropargyl aldehyde

D-3-phenylprop-2-yn-1-ol

Downstream raw materials:

C₁₅H₉⁽²⁾HClNO₂