(3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester

Base Information

• Chemical Name: (3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester
• CAS No.: 246240-13-1
• Molecular Formula: C₂₀H₁₆ClFN₂O₄
• Molecular Weight: 402.809

Synonyms:(3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester

Chemical Property of (3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester

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Technology Process of (3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester

There total 1 articles about (3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3-amino-phenyl)-acetic acid methyl ester (52913-11-8) + 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride (69399-79-7) → (3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester (246240-13-1)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/S0960-894X(02)00051-3

Reference yield: 53.0%

(3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester (246240-13-1) → [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetic acid (246238-45-9)

Guidance literature:

With sodium hydroxide; In methanol; N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1016/S0960-894X(02)00051-3

Reference yield:

(3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester (246240-13-1) → [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride (246240-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / 2 N NaOH / methanol; dimethylformamide / 2 h / 25 °C

2: 100 percent / (COCl)2 / CH₂Cl₂ / 1 h

With sodium hydroxide; oxalyl dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00051-3

upstream raw materials:

(3-amino-phenyl)-acetic acid methyl ester

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

Downstream raw materials:

[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetic acid

[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride

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