8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ⁵-phospha-cyclopenta[b]naphthalen-9-one

Base Information

• Chemical Name: 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ⁵-phospha-cyclopenta[b]naphthalen-9-one
• CAS No.: 145744-01-0
• Molecular Formula: C₅₂H₆₅N₆O₈PSi
• Molecular Weight: 961.183

Synonyms:8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ⁵-phospha-cyclopenta[b]naphthalen-9-one

Chemical Property of 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ⁵-phospha-cyclopenta[b]naphthalen-9-one

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Technology Process of 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ⁵-phospha-cyclopenta[b]naphthalen-9-one

There total 3 articles about 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ⁵-phospha-cyclopenta[b]naphthalen-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8-phospha-cyclopenta[b]naphthalen-9-one → 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ5-phospha-cyclopenta[b]naphthalen-9-one (145744-01-0)

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)61764-1

Reference yield:

N,N-diisopropylphosphoramide dichloride (921-26-6) → 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ5-phospha-cyclopenta[b]naphthalen-9-one (145744-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / (i-Pr)2NEt / 0.17 h / Ambient temperature

2: 78 percent / (CH₃)3COOH / CH₂Cl₂ / 4 h / Ambient temperature

With tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)61764-1

Reference yield:

N2-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine (101904-17-0) → 8-Diisopropylamino-3-{(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-8-oxo-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8λ5-phospha-cyclopenta[b]naphthalen-9-one (145744-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / (i-Pr)2NEt / 0.17 h / Ambient temperature

2: 78 percent / (CH₃)3COOH / CH₂Cl₂ / 4 h / Ambient temperature

With tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)61764-1

upstream raw materials:

N,N-diisopropylphosphoramide dichloride

N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine

Downstream raw materials:

C₆₁H₈₂N₈O₉P₂Si

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