2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

Base Information

Chemical Name:2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate
CAS No.:1390644-52-6
Molecular Formula:C₂₆H₃₆BrNO₃
Molecular Weight:490.481
Hs Code.:

Synonyms:2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

Suppliers and Price of 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

There total 22 articles about 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71271-28-8
3-bromo-2-methylpropanoyl chloride

: 207679-81-0
(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

: 1390644-52-6
2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 5 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 621-82-9
Cinnamic acid

: 1390644-52-6
2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; acetic acid / 16 h / 100 °C

2: acetone / 2 h / 25 - 35 °C

3: boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -20 °C

4: hydrogen / 5%-palladium/activated carbon / methanol / 18 h / 25 - 35 °C / 2942.29 Torr / autoclave

5: potassium carbonate / acetone / 6 h / Reflux

6: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 5 °C / Inert atmosphere

With sulfuric acid; boron trifluoride diethyl etherate; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetone;

Reference yield:

: (+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropane-1-ol

: 1390644-52-6
2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C

2.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere

3.1: isopropyl alcohol / 30 - 55 °C

4.1: sodium hydroxide; water / dichloromethane / 0.25 h / 10 - 20 °C / pH 11.5

4.2: 4 h / 25 - 55 °C / Inert atmosphere

4.3: -70 - -10 °C / Inert atmosphere

5.1: thionyl chloride / 5 h / 40 - 45 °C

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 0 - 5 °C / Inert atmosphere

7.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr

8.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 5 °C / Inert atmosphere

With dmap; thionyl chloride; water; hydrogen; sodium hydrogencarbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; 5%-palladium/activated carbon; In methanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile;