4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

Base Information

Chemical Name:4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester
CAS No.:1165799-98-3
Molecular Formula:C₃₁H₃₇N₃O₅
Molecular Weight:531.652
Hs Code.:

Synonyms:4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

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Chemical Property of 4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

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Technology Process of 4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

There total 3 articles about 4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1165799-99-4
2-[4-(methoxycarbonyl)phenyl]quinoline-4-carboxylic acid

: 166168-16-7
trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester

: 1165799-98-3
4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

Guidance literature:: 2-[4-(methoxycarbonyl)phenyl]quinoline-4-carboxylic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 5467-57-2
2-chloroquinoline-4-carboxylic acid

: 1165799-98-3
4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1165799-98-3
4-(4-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]carbamoyl}quinolin-2-yl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.014