(S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

Base Information

Chemical Name:(S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol
CAS No.:1380244-46-1
Molecular Formula:C₁₇H₂₆O₄
Molecular Weight:294.391
Hs Code.:

Synonyms:(S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

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Chemical Property of (S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

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Technology Process of (S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

There total 2 articles about (S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1380244-45-0
(S)-4-benzyl-3-((R)-2-((2S,4R,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanoyl)oxazolidin-2-one

: 1380244-46-1
(S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/anie.201109080

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 1380244-46-1
(S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1 h / 40 °C / 1.2 Torr / Inert atmosphere

2: lithium borohydride / tetrahydrofuran; methanol / 3 h / 0 - 20 °C / Inert atmosphere

With lithium borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1002/anie.201109080

Reference yield:

: 1380244-46-1
(S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

: 1380244-47-2
(R)-2-((2S,4R,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal

Guidance literature:: (S)-2-((2S,4S,5R,6S)-6-ethyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201109080