(2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

Base Information

Chemical Name:(2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone
CAS No.:108732-21-4
Molecular Formula:C₂₄H₃₇NO₆Si
Molecular Weight:463.646
Hs Code.:

Synonyms:(2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

Suppliers and Price of (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

There total 5 articles about (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 108732-21-4
(2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / LiBH₄ / tetrahydrofuran / 15 h / 5 °C

2: 98 percent / TEA, 4-DMAP / dimethylformamide / 3 h / Ambient temperature

3: 90 percent / RuO₂ hydrate, 10percent aqueous NaIO₄ / ethyl acetate / 1 h / Ambient temperature

4: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h

With dmap; ruthenium(IV) oxide; sodium periodate; lithium borohydride; n-butyllithium; TEA; diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 108732-21-4
(2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / TEA, 4-DMAP / dimethylformamide / 3 h / Ambient temperature

2: 90 percent / RuO₂ hydrate, 10percent aqueous NaIO₄ / ethyl acetate / 1 h / Ambient temperature

3: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h

With dmap; ruthenium(IV) oxide; sodium periodate; n-butyllithium; TEA; diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 108732-20-3
(2S)-1-(tert-Butoxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>pyrrolidine

: 108732-21-4
(2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / RuO₂ hydrate, 10percent aqueous NaIO₄ / ethyl acetate / 1 h / Ambient temperature

2: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h

With ruthenium(IV) oxide; sodium periodate; n-butyllithium; diisopropylamine; In ethyl acetate;