Technology Process of (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone
There total 5 articles about (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-(tert-butyldimethylsilyl)oxymethyl-5-pyrrolidone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / LiBH4 / tetrahydrofuran / 15 h / 5 °C
2: 98 percent / TEA, 4-DMAP / dimethylformamide / 3 h / Ambient temperature
3: 90 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 1 h / Ambient temperature
4: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h
With
dmap; ruthenium(IV) oxide; sodium periodate; lithium borohydride; n-butyllithium; TEA; diisopropylamine;
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / TEA, 4-DMAP / dimethylformamide / 3 h / Ambient temperature
2: 90 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 1 h / Ambient temperature
3: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h
With
dmap; ruthenium(IV) oxide; sodium periodate; n-butyllithium; TEA; diisopropylamine;
In
ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 1 h / Ambient temperature
2: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h
With
ruthenium(IV) oxide; sodium periodate; n-butyllithium; diisopropylamine;
In
ethyl acetate;
