Technology Process of ethyl 2-bromo-2-(3-(trifluoromethyl)phenyl)propanoate
There total 2 articles about ethyl 2-bromo-2-(3-(trifluoromethyl)phenyl)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-(3-(trifluoromethyl)phenyl)propionate;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
Inert atmosphere;
With
chloro-trimethyl-silane;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 2h;
Inert atmosphere;
With
N-Bromosuccinimide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jacs.7b05468
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; [bis(acetoxy)iodo]benzene
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
2.3: 2 h / -78 - 20 °C / Inert atmosphere
With
n-butyllithium; [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/jacs.7b05468
- Guidance literature:
-
With
D-glucose; glucose dehydrogenase GDH-105; gluconobacter oxydans enoate reductase (GluER), mutant Y177F; nicotinamide adenine dinucleotide phosphate;
In
isopropyl alcohol;
at 25 ℃;
for 24h;
pH=8;
Overall yield = 75 %; enantioselective reaction;
Inert atmosphere;
Sealed tube;
Enzymatic reaction;
DOI:10.1021/jacs.7b05468
