3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

Base Information

Chemical Name:3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol
CAS No.:885702-52-3
Molecular Formula:C₂₁H₂₅N₅O₄
Molecular Weight:411.461
Hs Code.:

Synonyms:3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

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Chemical Property of 3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

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Technology Process of 3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

There total 5 articles about 3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 885702-48-7
3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propionic acid ethyl ester

: 885702-52-3
3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.01.053

Reference yield:

: 280582-65-2
(5-bromo-2-chloro-pyrimidin-4-yl)-pyridin-2-yl-amine

: 885702-52-3
3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / butan-1-ol / 16 h / Heating

2: 75 percent / Pd(OAc)2 / acetonitrile / 16 h / Heating

3: 85 percent / H₂ / Pd/C / ethanol / 8 h / 25 °C

4: 60 percent / LAH / tetrahydrofuran / 2 h / 25 °C

With palladium diacetate; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile; butan-1-ol; 2: Heck coupling;
DOI:10.1016/j.bmcl.2006.01.053

Reference yield:

: 885702-45-4
bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

: 885702-52-3
3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Pd(OAc)2 / acetonitrile / 16 h / Heating

2: 85 percent / H₂ / Pd/C / ethanol / 8 h / 25 °C

3: 60 percent / LAH / tetrahydrofuran / 2 h / 25 °C

With palladium diacetate; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile; 1: Heck coupling;
DOI:10.1016/j.bmcl.2006.01.053