1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

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Chemical Name:1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene
CAS No.:1307304-48-8
Molecular Formula:C₂₄H₃₂N₆
Molecular Weight:404.558
Hs Code.:

Synonyms:1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

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Chemical Property of 1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

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Technology Process of 1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

There total 4 articles about 1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307304-47-7
(2S,2'S)-tert-butyl 2,2'-(4,4'-(2,2'-(1,4-phenylene)bis(ethane-2,1-diyl))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

: 1307304-48-8
1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

Guidance literature:: (2S,2'S)-tert-butyl 2,2'-(4,4'-(2,2'-(1,4-phenylene)bis(ethane-2,1-diyl))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1307304-48-8
1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / Inert atmosphere

2: ammonium acetate / toluene / Reflux

3: hydrogen / palladium 10% on activated carbon / methanol / 3 h

4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With ammonium acetate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1307304-46-6
(2S,2'S)-tert-butyl 2,2'-(4,4'-(1E,1'E)-2,2'-(1,4-phenylene)bis(ethene-2,1-diyl)bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

: 1307304-48-8
1-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)ethyl)-4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane;