4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile

Base Information

• Chemical Name: 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile
• CAS No.: 1426957-56-3
• Molecular Formula: C₂₇H₃₁N₃
• Molecular Weight: 397.563
• Mol file: 1426957-56-3.mol

Synonyms:4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile

Chemical Property of 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile

There total 10 articles about 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)butanenitrile (1426957-79-0) + 4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl trifluoromethanesulfonate (1436435-07-2) → 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile (1426957-56-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,2-dimethoxyethane; at 80 ℃;

DOI:10.1002/chem.201203006

Reference yield:

3,5-dibromopyridine (625-92-3) → 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile (1426957-56-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 120 °C / Schlenk technique

2.1: TurboGrignard / tetrahydrofuran / 2 h / -78 °C

2.2: -78 - 20 °C

3.1: thionyl chloride / dichloromethane / 21 h / -12 - 20 °C

4.1: TurboGrignard / tetrahydrofuran / 2.5 h / -78 °C

4.2: -78 - 20 °C

5.1: acetic acid; zinc / dichloromethane / 5 h / 20 °C

6.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 80 °C

With copper(l) iodide; TurboGrignard; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; sodium iodide; N,N`-dimethylethylenediamine; zinc; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 6.1: |Suzuki Coupling;

DOI:10.1002/chem.201203006

Reference yield:

3,5-diiodopyridine (53710-18-2) → 4-(5-(4-(5-isobutylpyridin-3-yl)-2-isopropylphenyl)pyridin-3-yl)butanenitrile (1426957-56-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: TurboGrignard / tetrahydrofuran / 2 h / -78 °C

1.2: -78 - 20 °C

2.1: thionyl chloride / dichloromethane / 21 h / -12 - 20 °C

3.1: TurboGrignard / tetrahydrofuran / 2.5 h / -78 °C

3.2: -78 - 20 °C

4.1: acetic acid; zinc / dichloromethane / 5 h / 20 °C

5.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 80 °C

With TurboGrignard; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 5.1: |Suzuki Coupling;

DOI:10.1002/chem.201203006

upstream raw materials:

1-(5-iodopyridin-3-yl)-2-methylpropan-1-ol

4-hydroxy-4-(5-iodopyridin-3-yl)butanenitrile

3-(1-chloro-2-methylpropyl)-5-iodopyridine

4-chloro-4-(5-iodopyridin-3-yl)butanenitrile