(4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

Base Information

Chemical Name:(4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol
CAS No.:1243560-24-8
Molecular Formula:C₂₁H₂₁F₃N₄O₂
Molecular Weight:418.419
Hs Code.:

Synonyms:(4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

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Chemical Property of (4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

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Technology Process of (4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

There total 5 articles about (4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₃F₃N₄O₃

: 1243560-24-8
(4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

Guidance literature:: With pyridine; In acetonitrile; at 150 ℃; for 0.5h; Irradiation with microwave;

Reference yield:

: 1140507-92-1
4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzonitrile

: 1243560-24-8
(4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 7 h / Heating; Reflux

1.2: 0 °C / pH 2

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C

3.1: pyridine / acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; acetonitrile;

Reference yield:

: 1140461-91-1
4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)benzoic acid

: 1243560-24-8
(4-(5-(4-(2-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 18 h / 20 °C

2: pyridine / acetonitrile / 0.5 h / 150 °C / Irradiation with microwave

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;