7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Base Information

Chemical Name:7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide
CAS No.:1335115-23-5
Molecular Formula:C₃₉H₄₂F₆N₄O₅S
Molecular Weight:792.843
Hs Code.:

7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Synonyms:7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Chemical Property of 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Technology Process of 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

There total 12 articles about 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1335116-72-7
7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 22038-85-3
(R)-(-)-2,2,2-Trifluoro-1-phenylethylamine

: 1335115-23-5
7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 0 - 20 ℃;

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1335115-23-5
7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.33 h

2.2: 2 h / 100 °C

2.3: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4.1: hydrogen bromide; acetic acid / 120 h / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

5.2: 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

8.1: acetonitrile / 3 h

9.1: potassium hydroxide; water / methanol / Reflux

9.2: pH 6

10.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0 - 20 °C

With N-Bromosuccinimide; oxalyl dichloride; water; hydrogen bromide; sodium hydride; caesium carbonate; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In methanol; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1335116-63-6
7-hydroxy-3-methyl-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 1335115-23-5
7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

1.2: 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

4.1: acetonitrile / 3 h

5.1: potassium hydroxide; water / methanol / Reflux

5.2: pH 6

6.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0 - 20 °C

With N-Bromosuccinimide; oxalyl dichloride; water; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In methanol; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;