(2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

Base Information

Chemical Name:(2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane
CAS No.:873925-38-3
Molecular Formula:C₂₄H₂₉F₃O₄
Molecular Weight:438.487
Hs Code.:

Synonyms:(2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

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Chemical Property of (2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

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Technology Process of (2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

There total 7 articles about (2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1-(1-chloro-ethoxymethyl)-4-trifluoromethyl-benzene

: 914914-46-8
(1S,3S)-3-Methoxy-1-((2S,3S)-3-methyl-oxiranyl)-4-phenyl-butan-1-ol

: 873925-38-3
(2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

Guidance literature:: With N,N-dimethyl-aniline; In dichloromethane;
DOI:10.1021/ol0261074 DOI:10.1016/j.tetasy.2005.08.055

Reference yield:

: 873925-36-1
((R)-2-Methoxy-pent-4-enyl)-benzene

: 873925-38-3
(2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

Guidance literature:: Multi-step reaction with 4 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: 51 percent / Ph₃P / CH₂Cl₂

2.1: 85 percent / LiAlH₄ / diethyl ether / Heating

3.1: 91 percent / Ti(Oi-Pr)4; (+)-diisopropyl tartrate; t-BuOOH / CH₂Cl₂ / -20 °C

4.1: 93 percent / N,N-dimethylaniline / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; ozone; N,N-dimethyl-aniline; In diethyl ether; dichloromethane; 3.1: Sharpless epoxidation;
DOI:10.1016/j.tetasy.2005.08.055

Reference yield:

: 873925-49-6
(4S,6S)-6-Methoxy-7-phenyl-hept-2-yn-4-ol

: 873925-38-3
(2R,3S)-2-{(1S,3S)-3-Methoxy-4-phenyl-1-[1-(4-trifluoromethyl-benzyloxy)-ethoxy]-butyl}-3-methyl-oxirane

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / LiAlH₄ / diethyl ether / Heating

2: 91 percent / Ti(Oi-Pr)4; (+)-diisopropyl tartrate; t-BuOOH / CH₂Cl₂ / -20 °C

3: 93 percent / N,N-dimethylaniline / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; N,N-dimethyl-aniline; In diethyl ether; dichloromethane; 2: Sharpless epoxidation;
DOI:10.1016/j.tetasy.2005.08.055