N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

Base Information

Chemical Name:N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide
CAS No.:1609355-47-6
Molecular Formula:C₂₄H₁₈ClFN₄O₄S
Molecular Weight:512.949
Hs Code.:

Synonyms:N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

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Chemical Property of N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

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Technology Process of N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

There total 6 articles about N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1609356-21-9
4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzoic acid

: 1609355-89-6
4-chloro-3-(1,6-naphthyridin-5-yl)aniline

: 1609355-47-6
N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 867333-29-7
(2-chloro-5-nitrophenyl)boronic acid

: 1609355-47-6
N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / ethanol; water; toluene / 3.5 h / 90 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethanol / 2 h / 70 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki-Miyaura Coupling;

Reference yield:

: 1609356-20-8
methyl 4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzoate

: 1609355-47-6
N-(4-chloro-3-(1,6-naphthyridin-5-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.17 h / 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;