N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Base Information

• Chemical Name: N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline
• CAS No.: 224577-17-7
• Molecular Formula: C₄₅H₅₃N₅O₈
• Molecular Weight: 791.945

Synonyms:N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Chemical Property of N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

Chemical Property:

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Technology Process of N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline

There total 11 articles about N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-<<<(2-methylphenyl)amino>carbonyl>amino>phenylacetate N-hydroxysuccinimide ester (224577-14-4) + L-leucyl-L-(α-O-benzylaspartyl)-L-valine benzyl ester hydrochloride → N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline (224577-17-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

DOI:10.1021/jm980673g

Reference yield:

Boc-Leu-ONSu (3392-09-4) → N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline (224577-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 92 percent / 4 M HCl / dioxane / 2 h / Ambient temperature

3: 84 percent / Et₃N / dimethylformamide / 3 h / Ambient temperature

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980673g

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-O-benzylvaline (224577-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / dimethylformamide / 1 h

2: SOCl₂ / acetonitrile / 0.17 h

3: Et₃N / acetonitrile / 2 h

4: 84 percent / Et₃N / dimethylformamide / 3 h / Ambient temperature

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm980673g

upstream raw materials:

4-<<<(2-methylphenyl)amino>carbonyl>amino>phenylacetate N-hydroxysuccinimide ester

Boc-Leu-ONSu

4-aminophenylacetic acid

N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

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