2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

Base Information

Chemical Name:2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine
CAS No.:188824-19-3
Molecular Formula:C₃₂H₃₆N₂O₃
Molecular Weight:496.649
Hs Code.:

Synonyms:2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

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Chemical Property of 2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

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Technology Process of 2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

There total 10 articles about 2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 188824-23-9
2,8-dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthrid-6-one

: 188824-19-3
2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1021/jm0101601

Reference yield:

: 3040-44-6
1-piperidinoethanol

: 188824-19-3
2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / triphenylphosphine; DEAD / tetrahydrofuran / 72 h / 20 °C

2: 64 percent / lithium aluminium hydride / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Mitsunobu alkylation;
DOI:10.1021/jm0101601

Reference yield:

: 17918-14-8
2,5-dimethoxybenzoyl chloride

: 188824-19-3
2,8-Dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-11,12-dihydro-6H-benzo[c]phenanthridine

Guidance literature:: Multi-step reaction with 5 steps

1: 48.7 g / Et₃N / CH₂Cl₂ / 60 h / Heating

2: 26 percent / benzene / 22 h / UV-irradiation

3: hydrogen fluoride-pyridine / acetonitrile; CH₂Cl₂ / 1 h

4: 56 percent / triphenylphosphine; DEAD / tetrahydrofuran / 72 h / 20 °C

5: 64 percent / lithium aluminium hydride / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; pyridine hydrogenfluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile; benzene; 4: Mitsunobu alkylation;
DOI:10.1021/jm0101601