5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester

Base Information

• Chemical Name: 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester
• CAS No.: 1416951-68-2
• Molecular Formula: C₄₂H₄₃N₃O₈
• Molecular Weight: 717.819
• Mol file: 1416951-68-2.mol

Synonyms:5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester

Chemical Property of 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester

There total 5 articles about 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(Z)-4-oxo-4-(((3S,4S,5R,6R)-1,2,3,4-di-O-isopropylidenetetrahydro-2H-pyran-2-yl)methylamino)but-2-enoic acid (1416951-65-9) + diazodiphenylmethane (908093-98-1) → 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester (1416951-68-2)

Guidance literature:

In ethyl acetate; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetasy.2012.11.005

Reference yield:

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose (4064-06-6) → 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester (1416951-68-2)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 10 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 10 h

3: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h

4: dichloromethane

5: ethyl acetate / 2 h / 40 °C / Inert atmosphere

With sodium azide; 5%-palladium/activated carbon; hydrogen; In pyridine; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2012.11.005

Reference yield:

6-azido-6-deoxy-1,2:3,4-di-O-isopropylidene-D-galactopyranose (4711-00-6) → 5,5-diphenyl-3-[(2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-5-ylmethyl)carbamoyl]-4,5-dihydro-1H-pyrazole-4-carboxylic acid benzhydryl ester (1416951-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h

2: dichloromethane

3: ethyl acetate / 2 h / 40 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; In ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.tetasy.2012.11.005

upstream raw materials:

(Z)-4-oxo-4-(((3S,4S,5R,6R)-1,2,3,4-di-O-isopropylidenetetrahydro-2H-pyran-2-yl)methylamino)but-2-enoic acid

diazodiphenylmethane

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

6-azido-6-deoxy-1,2:3,4-di-O-isopropylidene-D-galactopyranose