[4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester
CAS No.:934715-07-8
Molecular Formula:C₄₀H₅₈N₆O₇
Molecular Weight:734.937
Hs Code.:

Synonyms:[4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

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Chemical Property of [4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

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Technology Process of [4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

There total 13 articles about [4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 934715-86-3
2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid

: 934715-07-8
[4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo061830j

Reference yield:

: 934715-68-1
2-(2-{2-[6-benzyloxycarbonylamino-2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

: 934715-07-8
[4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl; anisole / tetrahydrofuran

2: 20 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / 3-(diethoxyphosphoryloxy)-3H-benzo[d][1,2,3]triazin-4-one / acetonitrile; tetrahydrofuran; CH₂Cl₂

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo061830j

Reference yield:

: 789428-88-2
(R)-2-((R)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

: 934715-07-8
[4-(11-benzyl-8,14-diisobutyl-5-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄ / CH₂Cl₂ / 20 °C

2: 100 percent / trifluoroacetic acid; anisole / CH₂Cl₂

3: 42 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / 3-(diethoxyphosphoryloxy)-3H-benzo[d][1,2,3]triazin-4-one / acetonitrile / 20 °C

4: HCl; anisole / tetrahydrofuran

5: 20 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / 3-(diethoxyphosphoryloxy)-3H-benzo[d][1,2,3]triazin-4-one / acetonitrile; tetrahydrofuran; CH₂Cl₂

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo061830j